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UPMC Transplant Services The Aging Institute UPMC Hillman Cancer Center

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT) (NCT01852370)

Our organization is conducting a study for patients with primary immunodeficiency and end-stage lung disease. Patients with immunodeficiencies often develop lung complications or infections that make them ineligible for life-saving immunotherapy.

In this study, we are performing a lung transplant as well as a bone marrow transplant from the same donor.

The bone marrow transplant will provide stem cells that should generate a new immune system in the patient, which we expect will resolve the patient’s immunodeficiency and prevent organ rejection.

Initiated by the UPMC Immune Transplant and Therapy Center.

  Trial Eligibility

This trial is open to pediatric and adult patients between the ages 10 and 45. For additional requirements and criteria please visit the NIH Clinical Trials website.

Study Start Date: June 20, 2013
Estimated Primary Completion Date: November 2023
Estimated Study Completion Date: November 2024

Learn more about this trial on its NIH Clinical Trials webpage or contact Shawna McIntyre, BSN, RN, at mcintyresm@upmc.edu or 412-692-5552.

  Lab Team

Principal Investigators:
Paul Szabolcs, MD
John McDyer, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

© 2023 UPMC – The UPMC Immune Transplant and Therapy Center is a partnership between UPMC and the University of Pittsburgh.

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