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UPMC Hillman Cancer Center The Aging Institute UPMC Transplant Services

T-Cell Depleted, Alternative Donor Transplant in Pediatric and Adult Patients with Severe Sickle Cell Disease SCD and Other Transfusion-Dependent Anemias (NCT03653338)

The trial, T-Cell Depleted, Alternative Donor Transplant in Pediatric and Adult Patients with Severe Sickle Cell Disease SCD and Other Transfusion-Dependent Anemias, will include T and B-cell depletion of an HLA-mismatched graft, obtained from mobilized blood of healthy, unrelated donors.

The reduced intensity regimen paired with immune-ablative conditioning is expected to preserve fertility, prevent severe GVHD, and minimize the possibility of immune rejection in patients with sickle cell disease and other transfusion-dependent anemias such as beta-thalassemia or Diamond-Blackfan anemia.

The protocol targets full or high grade mixed donor engraftment to facilitate resolution of disease-related symptoms and improve quality of life.

  Eligibility

This study is open to children and adults between the ages of 5-40 years. For additional requirements and criteria please visit visit the NIH Clinical Trials website.

Start Date: August 2, 2018

Learn more about this trial on its clinicaltrials.gov page or contact Shawna McIntyre, BSN, RN at mcintyresm@upmc.edu.

  Project Team

Principal Investigator:
Beth Carella, DO

Team Members:
Laura De Castro, MD
Mark Gladwin, MD
Dwight Heron, MD
Cheryl Hillery, MD
Annie Im, MD
Enrico Novelli, MD
Adam Olson, MD
Elizabeth Stenger, MD
Paul Szabolcs, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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