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Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells PBSC in Pediatric and Adult Patients with Severe Crohn’s Disease (NCT00692939)

The trial, Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Adult Patients with Severe Crohn’s Disease is based on a novel, reduced intensity conditioning regimen, followed by autologous stem cell transplantation. Potentially, autoreactive lymphocytes will be depleted in the stem cell laboratory by CD34 selection following stem cell mobilization and collection.

We anticipate that after lymphocyte depleted stem cell infusion, a normal immune system will reconstitute without recurrence of autoimmunity or to reduce disease burden even if recurrence was to take place eventually.

In addition, we propose this conditioning regimen is a safer strategy from a cardiopulmonary, urinary perspective compared to the published work from other centers, nevertheless, is paired with more intense immune suppression to lead to improved symptoms and prevent or delay Crohn’s disease recurrence.

  Eligibility

This study is open to children and adults between the ages of 10-60 years. For additional requirements and criteria please visit visit the NIH Clinical Trials website.

Start Date: December 5, 2017

Learn more about this trial on its clinicaltrials.gov page or contact Shawna McIntyre, BSN, RN at mcintyresm@upmc.edu.

  Project Team

Principal Investigator:
Paul Szabolcs, MD

Team Members:
David Binion, MD
Annie Im, MD
David Keljo, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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