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Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001) (NCT02631044)

This open-label Phase 1 study will evaluate the safety, PK, and antitumor activity of modified T cells (JCAR017) administered to adult patients with relapsed or refractory B-cell NHL.

The dose and schedule of JCAR017 will be evaluated and modified, as needed, for safety and antitumor activity. We will also determine how long the modified T cells stay in the patient’s body and how well JCAR017 works in treating patients with non-Hodgkin’s lymphoma whose disease has come back or has not responded to treatment.

Juno Therapeutics Inc. is the sponsor of this study.

 

 

  Trial Eligibility

This study is open to adults between 18 years of age and older. For additional requirements and criteria please visit the NIH Clinical Trials website.

Study Start Date: December 2015
Estimated Primary Completion Date: October 2018
Estimated Study Completion Date: April 2020

For more information, please call 1-833-UPMC-CART.

  Lab Team

Principal Investigator:
Alison Sehgal, MD

Co-Investigators:
Kathleen Dorritie, MD
Warren D. Shlomchik, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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