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  • Researchers conducting a cancer immunotherapy clinical trial | UPMC Immune Transplant and Therapy Center
    UPMC Hillman Cancer Center
  • Researchers discussing their immunotherapy clinical trial | UPMC Immune Transplant and Therapy Center
    The Aging Institute
  • Immunotherapy experts discussing their immune transplant clinical trial | UPMC Immune Transplant and Therapy Center
    UPMC Transplant Services

A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects with Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (ZUMA-5) (NCT03105336)

This study will enroll approximately 50 adult subjects who have relapsed or refractory (r/r) iNHL to be infused with the study treatment, axicabtagene ciloleucel, to see if their disease responds to this experimental product and if this product is safe.

Axicabtagene ciloleucel is made from the subject’s own white blood cells which are genetically modified and grown to fight cancer. An objective response rate of 70 percent is targeted.

Kite Pharma, Inc. is the sponsor of this study.

 

  Trial Eligibility

This study is open to adults between 18 years of age or older. For additional requirements and criteria please visit the NIH Clinical Trials website.

Actual Study Start Date: May 10, 2017
Estimated Primary Completion Date: December 2018
Estimated Study Completion Date: July 2023

For more information, please call 1-833-UPMC-CART.

  Lab Team

Principal Investigator:
Alison Sehgal, MD

Co-Investigators:
Kathleen Dorritie, MD
Warren D. Shlomchik, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

© 2021 UPMC – The UPMC Immune Transplant and Therapy Center is a partnership between UPMC and the University of Pittsburgh.

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