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UPMC Hillman Cancer Center The Aging Institute UPMC Transplant Services

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma (NCT03467516)

The purpose of this trial is to test the efficacy of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous TIL and high-dose aldesleukin in patients with metastatic uveal melanoma.

Eligible patients include those with metastatic uveal melanoma who are ≥ 18 years of age, and are physically able to tolerate non-myeloablative chemotherapy and high-dose aldesleukin.

Patients will undergo surgical biopsy or resection of a metastatic tumor on the companion protocol HCC 17-220 (Cell Harvest and Preparation to Support Adoptive Cell Therapy Clinical Protocols and Pre-Clinical Studies). There is no requirement for prior systemic therapies, given the lack of known effective systemic treatments for metastatic uveal melanoma.

Initiated by the UPMC Immune Transplant and Therapy Center.

  Trial Eligibility

This study is open to adults between 18 and 75 years of age. For additional requirements and criteria please visit the NIH Clinical Trials website.

Study Start Date: March 30, 2018
Estimated Primary Completion Date: April 1, 2020
Estimated Study Completion Date: August 1, 2021

For more information, please call 412-623-4861.

  Lab Team

Principal Investigator:
Udai Kammula, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

© 2023 UPMC – The UPMC Immune Transplant and Therapy Center is a partnership between UPMC and the University of Pittsburgh.

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