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Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) (NCT03331198)

This study will determine the safety and efficacy of JCAR017, a therapy that uses a patient’s own T-cells to fight cancer, in adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

The goal of this study is to determine the effect of JCAR017 and the recommended dose schedule. Phase one of this study will determine the recommended dose of JCAR017 monotherapy. The randomized Phase 2 portion will assess JCAR017 monotherapy treatment versus standard of care (SOC), with the possibility of crossover in patients on the SOC arm.

Juno Therapeutics is the sponsor of this study.

 

 

  Trial Eligibility

This study is open to adults between 18 years of age or older. For additional requirements and criteria please visit the NIH Clinical Trials website.

Actual Study Start Date: December 26, 2017
Estimated Primary Completion Date: October 1, 2019
Estimated Study Completion Date: March 1, 2021

For more information, please call Natalie Streeter, RN, MSN at 412-235-1276.

  Lab Team

Principal Investigator:
Kathleen Dorritie, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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