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Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma (NCT03108495)

This study will test whether patients with recurrent, metastatic, or persistent cervical carcinoma benefit from adoptive cell therapy (ACT) using their own tumor infiltrating lymphocytes (TILs).

TILs are a type of immune cell that can fight cancer. Patients will undergo a chemotherapy regimen, and then researchers will extract a tumor sample. The sample will be cultured in the laboratory to increase the number of TILs. Later, patients are reinfused with the autologous TIL (LN-145).

Iovance Biotherapeutics sponsors this study.

 

  Trial Eligibility

This study is open to adults between 18 years of age or older. For additional requirements and criteria please visit the NIH ClinicalTrials website.

Study Start Date: September 2015
Estimated Primary Completion Date: June 2018
Estimated Study Completion Date: January 2021

For more information, please call Amy Rose, RN, BSN, at 412-647-8587.

  Lab Team

Principal Investigator:
Robert P. Edwards, MD

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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