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Study of LN-145 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck (NCT03083873)

This study will test whether patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck benefit from adoptive cell therapy (ACT) using their own tumor infiltrating lymphocytes (TILs).

TILs are a type of immune cell that can fight cancer. Patients will undergo a chemotherapy regimen, and then researchers will extract a tumor sample. The sample will be cultured in the laboratory to increase the number of TILs. Later, patients are reinfused with the autologous TIL (LN-145).

Iovance Biotherapeutics sponsors this study.

 

 

  Trial Eligibility

This study is open to adults between 18 years of age or older. For additional requirements and criteria please visit the NIH Clinical Trials website.

Actual Study Start Date: January 9, 2017
Estimated Primary Completion Date: October 2018
Estimated Study Completion Date: August 2020

For more information, please call Amy Rose, RN, BSN, at 412-647-8587.

  Lab Team

Principal Investigator:
Robert Ferris, MD, PhD, FACS

Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

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