Immunotherapy Clinical Trials

At the UPMC Immune Transplant and Therapy Center, our researchers and doctors are bringing cutting-edge clinical trials directly to our patients.

Clinical trials initiated by the UPMC Immune Transplant and Therapy Center explore how we can:

• Harness the immune system to completely reimagine the way we treat transplant patients.
  • Meet our experts in organ transplantation.
• Find a way to control cancer from within.
  • Meet our experts in cancer treatment.
• Reduce the effects of chronic diseases as our patients age.
  • Meet our experts in treating the biology of aging.

1. Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT) (NCT01852370)

2. DCreg in Living Donor Liver Transplantation (NCT03164265)

3. Center for Medicine & the Microbiome

4. Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure (NCT03500731)

5. Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

Cancer

1. Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma (LN-144) (NCT02360579)

2. Study of LN-145 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck (NCT03083873)

3. Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma (NCT03108495)

4. A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects with Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (ZUMA-5) (NCT03105336)

5. Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001) (NCT02631044)

6. Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) (NCT03331198)

7. Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma (NCT03467516)

8. Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers (NCT03801083)

Chronic Diseases

1. Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells PBSC in Patients with Treatment Resistant Systemic Sclerosis (SSc) (NCT03630211)

2. T-Cell Depleted, Alternative Donor Transplant in Pediatric and Adult Patients with Severe Sickle Cell Disease SCD and Other Transfusion-Dependent Anemias (NCT03653338)

3. Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells PBSC in Pediatric and Adult Patients with Severe Crohn’s Disease (NCT00692939)