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Immunotherapy Clinical Trials

At the UPMC Immune Transplant and Therapy Center, our researchers and doctors are bringing cutting-edge clinical trials directly to our patients.

Clinical trials initiated by the UPMC Immune Transplant and Therapy Center explore how we can:

  • Harness the immune system to completely reimagine the way we treat transplant patients.
    • Meet our experts in organ transplantation.
  • Find a way to control cancer from within.
    • Meet our experts in cancer treatment.
  • Reduce the effects of chronic diseases as our patients age.
    • Meet our experts in treating the biology of aging.

The UPMC Immune Transplant and Therapy Center is also a collaborating and sometimes leading site for industry-sponsored trials researching:

  • Tumor infiltrating lymphocytes (TILs) for a range of metastatic and recurrent cancers.
  • Chimeric antigen receptor (CAR) T-cell therapies for refractory/relapsed lymphoma and leukemia.

Our researchers are also designing novel applications and enhancements of CAR T cells, with a focus on improving and optimizing their use.

Transplant

  1. Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT) (NCT01852370)

  2. DCreg in Living Donor Liver Transplantation (NCT03164265)

  3. Center for Medicine & the Microbiome

  4. Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure (NCT03500731)

  5. Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

Cancer

  1. Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma (LN-144) (NCT02360579)

  2. Study of LN-145 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck (NCT03083873)

  3. Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma (NCT03108495)

  4. A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects with Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (ZUMA-5) (NCT03105336)

  5. Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001) (NCT02631044)

  6. Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) (NCT03331198)

  7. Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma (NCT03467516)

  8. Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers (NCT03801083)

Chronic Diseases

  1. Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells PBSC in Patients with Treatment Resistant Systemic Sclerosis (SSc) (NCT03630211)

  2. T-Cell Depleted, Alternative Donor Transplant in Pediatric and Adult Patients with Severe Sickle Cell Disease SCD and Other Transfusion-Dependent Anemias (NCT03653338)

  3. Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells PBSC in Pediatric and Adult Patients with Severe Crohn’s Disease (NCT00692939)

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Contact Information

For more information, call the UPMC Immune Transplant and Therapy Center at 1-888-4UPMC-ITTC (1-888-487-6248).

UPMC
200 Lothrop St.
Pittsburgh, PA 15213-2582

Additional Resources

For patients:
UPMC Transplant Services
Immunotherapy at UPMC Hillman Cancer Center
The Aging Institute

For researchers:
Thomas E. Starzl Transplantation Institute
Cancer Immunotherapy Research at UPMC Hillman Cancer Center
University of Pittsburgh Department of Immunology

© 2023 UPMC – The UPMC Immune Transplant and Therapy Center is a partnership between UPMC and the University of Pittsburgh.

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